Initial Laboratory Assessment
Traditional lipid panel
Total cholesterol, LDL-C, HDL-C, triglycerides and non-HDL
Marker of atherogenic (plaque producing) particles, more predictive of cardiovascular risk than LDL cholesterol
Lipoprotein particle profile
Advanced cholesterol testing which accurately measures the number of lipoprotein particles. Studies have clearly demonstrated that elevated LDL particle concentration is associated with increased risk of heart disease even in the presence of normal LDL cholesterol. The presence of small LDL particles can indicate insulin resistance, metabolic syndrome, and prediabetes.
Genetic, highly atherogenic (plaque producing) particle associated with increased cardiovascular risk.
Insulin resistance score (IR Score)
Provides information about the risk for diabetes and also data that allows us to determine alternative treatment options for high cholesterol other than traditional therapies; also helps determine why patients may easily gain weight in the abdomen and have difficulty losing weight in general.
Absorption and Synthesis Markers
Determines if your liver is making too much cholesterol or you are over absorbing cholesterol. Helps determine the appropriate treatment for elevated cholesterol.
The test for Lp-PLA2 is the only blood test cleared by the FDA that helps to identify hidden risk for heart attack and stroke. When the Lp-PLA2 is elevated, it indicates arterial inflammation, making heart attack and stroke more likely.
Having a mutation on one or both of these genes can lead to decreased production of L-methylfolate, the body’s usable form of folate.
Omega 3 index
Determines omega 3 level in red blood cells. Low levels are associated with increased cardiovascular risk.
Used to assess platelet activity and associated increased risks for cardiaovascular events. Helps identify those individual in whom aspirin would be beneficial as well as monitoring response to the aspirin.
25 OH Vitamin D
Vitamin D deficiency is highly prevalent and associated with hypertension, inflammation, metabolic syndrome and increased cardiovascular risk.
Common deficiency which also may be depleted when using certain medications.
Thyroid Panel including TSH, FT4, FT3 and thyroid antibodies
Thyroid, if not functioning properly could play a role in high cholesterol. Antibodies detect an autoimmune disorder known as Hashimoto’s hypothyroid, which can cause symptoms of hypothyroid, including weight gain, hair loss and feeling cold, while thyroid labs labs remain normal.
An inflammatory marker that if elevated can be associated with increased risk of heart disease.
The CorusCAD gene expression test shows what is happening in your arteries right now. It is not a genetic test which provides information about future risk. Corus CAD measures the activity level of specific genes in your blood that likely reflect the amount of plaque currently in your arteries. Your Corus CAD score is calculated using your gene expression, gender, and age and can help rule out obstructive CAD.
Labwork may include additional genetic testing as determined by the provider:
- Apo E genotype
- Prothrombin Mutation
- Factor V Leiden